Abstract: Chuquicamata copper deposit is the largest porphyry copper deposit in the world.The paper summarizes the regional geological setting of the deposit formation,and in more detail describes the deposit from the following aspects:the alteration features,mineralization stages,diagenetic age,mineralization age and the destruction and preservation.The paper at last further analyses the genesis of the deposit,establishing the prospecting model and prospecting indicators of the deposit.The conclusion demonstrates that Chuquicamata copper deposit,located in the central Andean orogenic belt,occurs in the Chuquicamata intrusive rocks and is mainly controlled by the Western fracture.The alteration zonation of the deposit is distributed in irregular shape and mineralization is closely related to the quartz-sericitization.The deposit has developed oxidation zone,and contains atacamite and malachite,which is similar with Tuwu porphyry copper deposit in China.The deposit was formed in the Late Eocene-Early Oligocene.The diagenetic and metallogenic materials are derived from the mantle,and the ore-bearing porphyry has a high oxygen fugacity,which is similar with Yulong and Qulong porphyry copper deposits in China.The formation of the deposit had experienced a number of superimposed mineralization.Metallogenic dynamic studies indicate that the formation of the deposit is related to quick oblique subduction movement between the South American plate and the Farallon plate.The geological characteristics and ore-controlling factors of Chuquicamata copper deposit summarized in this paper will offer valuable references for the exploration of porphyry copper deposit in China.