Abstract: [Objective] The three-dimensional simulation of kinematics considering the characteristics of slope topography is an important basis for the evaluation of dangerous rocks collapse in mountainous highways, and its calculation results can also support the management of rockfall. [Methods] Based on field investigation and UAV aerial survey, the distribution, material composition and disaster characteristics of perilous rock in the study area were analyzed. RocPro3D software was used to simulate the three-dimensional kinematics of rockfall, evaluating the disaster damage, and calculating the engineering treatment effect of dangerous rock with different particle sizes and protective facilities. [Results] The results show that the combined joints caused by tectonic compression and air unloading cut the dangerous rock, and the weathering cavity at the bottom of the dangerous rock reduces its stability. The hydrostatic thrust of the trailing edge crack and the seepage of the crack are the typical causes of the rockfall. After the collapse of dangerous rock, the velocity and impact energy increase first and then decrease, and the bounce height fluctuates and tends to decrease. The dangerous rock zone in the study area poses a major threat to the management house at the foot of the slope. It is an effective disposal measure to clear the side to the dangerous rock with a diameter of less than 0.8 m, and to adopt a passive protection network with a height of 5.0 m and a protection level of 1000 kJ. The local concentration position of the spatial distribution of the rockfall movement trace should be properly enhanced. [Conclusion] The three-dimensional simulation of kinematics can obtain the information of movement trace, velocity, energy, bounce height and unit density of rockfall, which breaks through the limitation of two-dimensional section calculation in space and is of great significance to disaster damage evaluation and geological disaster prevention.